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目的:探讨温针灸联合经皮椎体后凸成形术(PKP)治疗肾虚血瘀型骨质疏松性椎体压缩性骨折(OVCF)的疗效及作用机制.方法:将70例OVCF患者随机分为对照组和观察组,每组35例.对照组予PKP治疗,观察组在此基础上加温针灸治疗.治疗前后进行视觉模拟量表(VAS)及Oswestry功能障碍指数(ODI)评分,测定伤椎Cobb角;随访1年,记录邻近椎体再骨折率;治疗前后测定血清转化生长因子(TGF)-β1和网膜素-1的水平.结果:治疗后,两组VAS和ODI评分均降低(均P<0.05),观察组VAS及ODI评分均低于对照组(均P<0.05).治疗后,两组伤椎Cobb角均减小(均P<0.05),观察组伤椎Cobb角小于对照组(P<0.05).随访1年,观察组邻近椎体再骨折率低于对照组(P<0.05).治疗后,两组患者血清TGF-β1和网膜素-1水平均明显升高(均P<0.05),且观察组血清TGF-β1和网膜素-1水平高于对照组(均P<0.05).结论:温针灸加PKP治疗肾虚血瘀型OVCF可缓解疼痛症状,改善功能障碍,促进伤椎愈合,降低邻近椎体再骨折率;这可能与其提升患者血清的TGF-β1和网膜素-1水平相关.“,”Objective: To explore the efficacy and mechanism of warm needling moxibustion plus percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fracture (OVCF) due to kidney deficiency and blood stasis. Methods: A total of 70 OVCF patients were randomized into a control group and an observation group, with 35 cases in each group. The control group was given PKP treatment, and the observation group was treated with warm needling moxibustion on the basis of the treatment in the control group. The visual analog scale (VAS) and Oswestry disability index (ODI) were scored and the Cobb angle of fractured vertebrae was measured before and after treatment. The re-fracture rate of the adjacent vertebrae was recorded at 1-year follow-up. The serum levels of transforming growth factor (TGF)-β1 and omentin-1 were measured before and after treatment. Results: After treatment, the VAS and ODI scores in both groups decreased (all P<0.05), and all the scores in the observation group were lower than those in the control group (both P<0.05). After treatment, the Cobb angle of fractured vertebrae in both groups decreased (both P<0.05), and the Cobb angle in the observation group was smaller than that in the control group (P<0.05). At 1-year follow-up, the re-fracture rate of the adjacent vertebrae in the observation group was lower than that in the control group (P<0.05). After treatment, the serum levels of TGF-β1 and omentin-1 in both groups increased significantly (all P<0.05), and the serum levels of TGF-β1 and omentin-1 in the observation group were higher than those in the control group (both P<0.05). Conclusion: The treatment of warm needling moxibustion plus PKP can relieve pain, improve dysfunction, promote healing of the injured vertebrae, and reduce the re-fracture rate of the adjacent vertebrae in patients with OVCF due to kidney deficiency and blood stasis, which may be related to the increase of serum TGF-β 1 and omentin-1 levels.