1980年底,引入4个非甾体抗炎药物作为外周作用的口服镇痛药。实验证实,它们对以前认为只能用麻醉性镇痛药治疗的各种疼痛都有效。有关内源性阿片类物质的研究继续迅速开展,包括各种阿片肽类的合成、失活脑啡肽的肽酶的纯化和鉴定、产生镇痛作用的强效专一抑制剂的发展、阿片亚型受体存在和各自功能的 By the end of 1980, four non-steroidal anti-inflammatory drugs were introduced as peripheral analgesics. Experiments have shown that they are effective on a variety of pains previously thought to be treatable only with narcotic analgesics. Research on endogenous opioids continues rapidly, including the synthesis of various opioid peptides, the purification and characterization of peptidases that inactivate enkephalins, the development of potent and specific inhibitors that produce analgesic effects, opioids Subtype receptors exist and function independently