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采用琼脂稀释法，测定了三种药物牙膏对四种口腔常驻菌的最低抑菌浓度（ＭＩＣ），结果表明，药物牙膏对口腔中的常驻菌有一定的抑制作用；提示，健康人长期使用药物牙膏，可能造成口腔微生态环境的失衡。
The agar dilution method was used to determine the minimum inhibitory concentration (MIC) of the three drug dentifrices against four oral resident bacteria. The results showed that the drug toothpaste had a certain inhibitory effect on the resident bacteria in the oral cavity; The use of drug toothpaste may cause an imbalance in the oral microecological environment.