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目的探讨口服避孕药(oral contraception pill,OCP)前期预处理对接受长效长方案控制性超排卵患者临床结局的影响。方法对2011年1月至2013年4月在广州市妇女儿童医疗中心生殖医学中心进行长效长方案治疗的正常卵巢储备患者325例的临床资料进行分析。采用OCP前期预处理的185例患者为OCP组,未采用OCP预处理140例患者为对照组。比较两组卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)发生率、促性腺激素用量与天数、获卵数、临床妊娠率、着床率。结果 OCP组OHSS发生率(5.9%)高于对照组(1.4%)(P<0.05);两组间促性腺激素的用量、获卵数、临床妊娠率、着床率比较差异无统计学意义(P>0.05)。结论长效长方案治疗中,OCP预处理可能增加了正常卵巢储备患者OHSS的发生率。
Objective To investigate the effect of preconditioning with oral contraception pill (OCP) on the clinical outcomes of patients with controlled ovarian hyperstimulation (OVA). Methods The clinical data of 325 patients with normal ovarian reserve who underwent long-term long-term regimen from January 2011 to April 2013 in Guangzhou Reproductive Medicine Center of Women and Children’s Medical Center were analyzed. One hundred and seventy five patients with OCP preconditioning were OCP group, and 140 patients without OCP pretreatment were control group. Ovarian hyperstimulation syndrome (OHSS) incidence, gonadotropin dosage and days, number of oocytes retrieved, clinical pregnancy rate and implantation rate were compared between the two groups. Results The incidence of OHSS in OCP group (5.9%) was higher than that in control group (1.4%) (P <0.05). There was no significant difference in gonadotropin dosage, number of oocytes retrieved, clinical pregnancy rate and implantation rate (P> 0.05). Conclusion OCP pretreatment may increase the incidence of OHSS in patients with normal ovarian reserve during long-term long-term regimen.