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目的:研究和分析抗病毒治疗对乙肝患者抗结核药物肝损伤的作用。方法:收集乙肝合并肺结核患者共88例,随机分为观察组与对照组,各44例,对照组患者进行抗结核治疗,观察组在此基础上进行抗病毒治疗,将两组患者的肝功能情况进行观察和对比。结果:观察组患者的谷丙转氨酶、谷草转氨酶以及血清总胆红素均明显低于对照组,观察组患者的肝功能异常率显著低于对照组,P均<0.05。结论:在乙肝合并肺结核患者的治疗过程中结合抗病毒治疗,能够有效降低对患者肝功能的损害,提高患者对治疗的依从性,值得推广应用。
Objective: To study and analyze the effect of antiviral therapy on anti-TB drug-induced liver injury in hepatitis B patients. Methods: A total of 88 patients with hepatitis B and pulmonary tuberculosis were collected and randomly divided into observation group and control group, with 44 cases in each group. Patients in the control group were treated with anti-TB therapy. The observation group was treated with antiviral therapy on this basis. The liver function The situation was observed and compared. Results: The alanine aminotransferase, aspartate aminotransferase and serum total bilirubin in the observation group were significantly lower than those in the control group. The abnormal liver function rate in the observation group was significantly lower than that in the control group (all P <0.05). Conclusion: The combined treatment of antiviral therapy in the treatment of patients with hepatitis B combined with pulmonary tuberculosis can effectively reduce the damage to the liver function of patients and improve the compliance of patients with the treatment, which is worth popularizing and applying.