糖尿病的发病率正日益提高。高血糖作为糖尿病的重要指征,通过非酶促的糖基化反应促进晚期糖基化终产物(AGEs)的生成。而AGEs在血液和组织中沉积,通过直接修饰蛋白质使基质功能和脂质代谢紊乱,通过受体介导的信号传导机制与参与动脉粥样硬化的细胞作用,促进动脉粥样硬化病变。动脉粥样硬化则是糖尿病常见的并发症和最重要死因[1-2]。长期暴露于高血糖环境被认为是糖尿病患者动脉粥样硬化的主要因素[3]。关于这一问题主要有3种解 The incidence of diabetes is increasing. Hyperglycaemia, an important indicator of diabetes, promotes the production of advanced glycation end products (AGEs) through non-enzymatic glycosylation. AGEs, however, are deposited in the blood and tissues and promote atherosclerotic lesions through direct modification of proteins to disrupt matrix functions and lipid metabolism, through receptor-mediated signaling and cellular involvement in atherosclerosis. Atherosclerosis is a common complication of diabetes and the most important cause of death [1-2]. Long-term exposure to hyperglycemic conditions is considered to be a major factor in atherosclerosis in diabetic patients [3]. There are three main solutions to this problem