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系统地综述濒危药用植物桃儿七中存在的天然木脂素类化学成分、人工合成鬼臼毒素衍生物及其生物活性、作用机理。目前研究主要集中在桃儿七中已知的木脂素类化合物的生物活性探讨、以鬼臼毒素为前体物质合成和发现低毒高效的抗肿瘤活性衍生物方面,并将是今后的主要研究方向。同时,由于目前作为前体物质的鬼臼毒素仍依赖于从桃儿七中提取,而桃儿七的资源已出现紧缺,寻找鬼臼毒素含量高的桃儿七野生资源,并开展人工种植基地建设也是不容忽视的工作。
The natural lignan chemical constituents present in the endangered medicinal plant Peach 7 were systematically reviewed. Synthesized podophyllotoxin derivatives and their biological activities and mechanism were systematically reviewed. At present, the research mainly focuses on the biological activities of lignan compounds known in peach seven, the synthesis of podophyllotoxin as a precursor and the discovery of low toxicity and high efficient anti-tumor derivatives, and will be the main research direction. At the same time, due to the current podophyllotoxin as a precursor material still depends on the extraction from Taosho seven, and Taosho seven resources have been in short supply, looking for podophyllotoxin high quality Taoyuan seven wild resources, and to carry out artificial planting base Construction can not be ignored.