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目的探讨成年人及儿童麻疹患者急性期与恢复期T淋巴细胞及调节性T淋巴细胞表达水平的变化。方法成年人及儿童麻疹患者各40例,用流式细胞术分别测定各组出疹期和恢复期患者外周血CD3+总T细胞、CD4+辅助性T细胞(Th)、CD8+细胞毒性T细胞(Tc)及CD4+CD2+5调节性T淋巴细胞(Treg)比例。结果成年人麻疹患者出疹期较对照期外周血CD3+总T和CD4+Th表达水平降低,CD4+CD2+5Treg表达水平升高,恢复期CD4+Th升高,CD8+Tc降低,CD4+/CD8+比值升高,CD4+CD2+5Treg降低。儿童麻疹患者出疹期较对照组CD3+总T、CD4+Th降低,恢复期较出疹期CD3+总T表达回升。结论 T淋巴细胞及调节性T淋巴细胞参与成年人及儿童麻疹患者免疫状态的调节,但其表达水平在成年人和儿童中有差异。
Objective To investigate the changes of T lymphocytes and regulatory T lymphocytes in acute and convalescent adult and childhood measles patients. Methods Forty adult and pediatric measles patients were divided into two groups. Flow cytometry was used to measure the levels of CD3 + T cells, CD4 + T cells, CD8 + cytotoxic T cells (Tc ) And CD4 + CD2 + 5 regulatory T lymphocyte (Treg) ratio. Results The levels of CD3 + T and CD4 + Th in peripheral blood of measles patients were lower than those in the control period, the expression of CD4 + CD2 + 5Treg was increased, CD4 + Th was elevated, CD8 + Tc was decreased, CD4 + / CD8 + Ratio increased, CD4 + CD2 + 5Treg decreased. Measles patients with measles rash than the control group, total T, CD4 + Th decreased during recovery than during rash CD3 + T expression. Conclusions T lymphocytes and regulatory T lymphocytes are involved in the regulation of immune status in adult and pediatric measles patients, but their expression levels are different between adults and children.