生物被膜(BF)是指由于单一或多种类群细菌为了适应周围环境,吸附于机体黏膜或植入性生物医学材料表面并分泌多糖基质、纤维蛋白、脂蛋白等多糖蛋白复合物,使得细菌相互粘连、聚集、缠绕,形成具有三维立体结构的膜样物。BF的相关理论是由Costerton等[1]于1978年首次提出,美国疾 Biofilm (BF) refers to the fact that single or multiple groups of bacteria adsorb to the mucosa of the body or the surface of implantable biomedical materials to secrete polysaccharide matrix, fibrin, lipoprotein and other polysaccharide protein complex in order to adapt to the surrounding environment, Adhesion, aggregation, winding, forming a three-dimensional structure of the membrane sample. The related theory of BF was first proposed by Costerton et al. [1] in 1978, and the American disease