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目的：探讨利凡诺羊膜腔穿刺术配伍米索前列醇用于中期妊娠引产的安全性及效果。方法：将３００例中期妊娠要求终止妊娠、无禁忌证的孕妇随机分为：研究组（１５０例）于利凡诺羊膜腔穿刺术后立即阴道后穹窿置入米索前列醇４００μｇ；对照组（１５０例）：单纯采用利凡诺羊膜腔穿刺术。结果：研究组初产妇及经产妇的引产成功率均为１００％，明显优于对照组的８６．２％、９２．４％，差异有显著性（Ｐ值均＜０．０５）；研究组的总成功率为１００％，对照组为９０．０％，两组比较差异亦有显著性（Ｐ＜０．００１）；研究组中初产妇及经产妇的引产时间分别为（１９．１±５．１０）ｈ、（１６．６±５．２）ｈ，明显少于对照组的（４０．５±８．０）ｈ及（３８．９±５．６）ｈ，差异有显著性（Ｐ值均＜０．００１）；产后出血量及清宫率两组比较差异无显著性（Ｐ＞０．０５）。结论：利凡诺羊膜腔穿刺术配伍米索前列醇可明显提高中期引产成功率，缩短引产时间及平均住院时间，是安全、有效的中期引产方法
Objective: To investigate the safety and efficacy of rivanol amniocentesis combined with misoprostol in induction of labor during mid-term pregnancy. Methods: A total of 300 pregnant women with interim pregnancy and no contraindication were randomly divided into study group (150 cases), misoprostol (400μg) immediately after amniocentesis in rivanol group, control group 150 cases): simple rivano amniocentesis. Results: The success rate of induction of labor of primipara and maternal in study group was 100%, which was significantly better than that of control group (86.2%, 92.4%), the difference was significant (P <0.05) The total success rate was 100% in the control group and 90.0% in the control group. There was also significant difference between the two groups (P <0.001). The induced labor time of primipara and maternal women in the study group were (19.1 ± 5.10) h, (16.6 ± 5.2) h, significantly less than the control group (40.5 ± 8.0) h and (38.9 ± 5.6) h, the difference was significant ( P values were <0.001); postpartum hemorrhage and clearance rates were no significant difference between the two groups (P> 0.05). Conclusion: Rivanol amniocentesis combined with misoprostol can significantly improve the success rate of mid-term induction of labor, shorten the induction of labor and the average length of stay, is a safe and effective mid-term induction of labor