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Many health benefits have been ascribed to allicin, including vasorelaxant activities.1However, the molecular mechanisms underlying these effects remain unknown. To apply allicin in clinical anti-HCC treatment, different doses of allicin and Adriamycin (ADM) were led into transplanted tumor model established by injecting HCC BEL7402cells into subcutaneous tissue of nude mice.Treatment with allicin and ADM resulted in tumor regression with inducing of Bax and Fas ligand (FasL) mRNA.