[Objective] To optimize the extraction process of astragaloside IV from ASTRAGALI RADIX. [Method] Using TS-NS extraction and concentration industrial equipment to extract ASTRAGALI RADIX, effects of ethanol concentration, solid-liquid ratio, extraction time and extraction times on the yield of astragaloside IV were respectively investigated by uniform design experiment. Taking the content of astragaloside IV determined by HPLC-ELSD as index, the extraction process was optimized. [Result] The optimum extraction process of astragaloside IV from ASTRAGALI RADIX was: ethanol concentration of 80%, solid-liquid ratio of 1∶ 8 g/ml, extraction times of 3 and extraction time of 1 h. [Conclusion] The optimum process for extracting astragaloside IV was simple, reliable and more suitable for industrial production compared with the reported methods. [Objective] To optimize the extraction process of astragaloside IV from ASTRAGALI RADIX. [Method] Using TS-NS extraction and concentration industrial equipment to extract ASTRAGALI RADIX, effects of ethanol concentration, solid-liquid ratio, extraction time and extraction times on the yield of the astragaloside IV were respectively investigated by uniform design experiment. Taking the content of astragaloside IV determined by HPLC-ELSD as index, the extraction process was optimized. [Result] The optimum extraction process of astragaloside IV from ASTRAGALI RADIX was: ethanol concentration of 80 %, solid-liquid ratio of 1: 8 g / ml, extraction times of 3 and extraction time of 1 h. [Conclusion] The optimum process for extracting astragaloside IV was simple, reliable and more suitable for industrial production compared with the reported methods .