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IL-2是维持T细胞体外繁殖的生长因子,是一种结构已清楚的糖蛋白激素。T、B淋巴细胞以及具有杀伤活性的大颗粒淋巴细胞(NK细胞)都能对IL-2起反应,IL-2的作用似乎仅限于淋巴细胞。本文的实验结果提示重组IL-2可以促进人末梢血中的单核细胞对瘤细胞T_(24)的溶解作用。作者用抗淋巴细胞单克隆抗体、CAMP-ATHI以及同种血清作为补体来源对IL-2诱导杀伤性T细胞(LAK细胞)进行处理,发现可以消除LAK细胞的细胞毒活性,但对IL-2诱导的单核细胞的细胞毒活性则无影响。为了研究单核细胞的细胞毒活性是否直接由IL-2介导,作者用T_(24)瘤细胞作为靶细胞,结果看到该细胞的特点是能抵抗NK。细
IL-2 is a growth factor that maintains the in vitro proliferation of T cells and is a well-structured glycoprotein hormone. T, B lymphocytes and large granulocyte lymphocytes (NK cells) with cytotoxic activity are able to respond to IL-2, the role of IL-2 seems to be limited to lymphocytes. Our results suggest that recombinant IL-2 can promote the T (24) lysis of monocytes in human peripheral blood. The authors treated IL-2-induced killer T cells (LAK cells) with anti-lymphocyte monoclonal antibodies, CAMP-ATHI and allo-sera as sources of complement and found that LAK cells can be eliminated cytotoxic activity, but IL-2 Induced monocyte cytotoxicity has no effect. To investigate whether monocyte cytotoxicity is directly mediated by IL-2, the authors used T_ (24) tumor cells as target cells and found that the cells were characterized by resistance to NK. fine