多灶性运动神经病(MMN)是指临床特征为进行性、偏侧肢体乏力、电生理表现为多灶性传导阻滞的一种疾病,其发病机制不明,一些病人体内有较高的抗GM_1抗体,免疫抑制剂治疗有效,故认为是一种免疫调解性(immune—mediated)疾病。通常的报告提示人体免疫球蛋白(HIG)治疗对MMN有短暂的疗效,而几乎没有HIG作为主要治疗而长期有效的报道,作者在此报道1例。 Multifocal motor neuropathy (MMN) is a disease characterized by progressive, unilateral limb weakness, and electrophysiological manifestations of multifocal blockade. The pathogenesis of this disease is unknown. Some patients have higher anti-GM1 Antibodies and immunosuppressive agents are effective and therefore considered an immune-mediated disease. The usual reports suggest that human immunoglobulin (HIG) therapy has a transient response to MMN with few long-term reports of HIG as the primary treatment, the authors reported here.