8例原发性开角型青光眼(POAG)(16只眼)患者,在研究前的第一个2周均接受0.6%美替洛尔点眼,一日2次。然后从上午9时至下午5时(每2小时一次读数,共5次)测定眼内压(IOP)。此后,联用0.6%美替洛尔和1%肾上腺素于上午8时和下午8时点眼。4例先用美替洛尔,另4例则先用肾上腺素,在两种滴眼剂之间间隔10分钟。在下一个2周,病人的IOP再次调整,并把两种滴眼剂的使用顺序颠倒过来。结果发现,所有联合用药患者,与单用美 Eight patients with primary open-angle glaucoma (POAG) (16 eyes) received 0.6% metipranolol twice a day for the first 2 weeks prior to the study. Intraocular pressure (IOP) was then determined from 9 a.m. to 5 p.m. (readings taken every 2 hours for 5 times). Since then, 0.6% metipranolol and 1% adrenaline have been used at 8 am and at 8 pm. 4 cases first metoprolol, and the other 4 cases first with adrenaline, the interval between the two eye drops 10 minutes. In the next two weeks, the patient’s IOP was adjusted again and the order of use of both eye drops reversed. The results showed that all combination patients, and the United States alone