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目的:用小鼠和大鼠对双氯芬酸钾(DK)原粉进行镇痛、抗炎的药效作用及急性毒性评价。方法 角叉菜胶致大鼠足跖肿胀法,二甲苯致小鼠耳廓肿胀法,热板法及扭体法。结果:抗炎试验结果显示,单次口服DK5.0～20.0mg·kg-1对角叉菜胶所致大鼠足跖肿胀的抑制作用显著(P<0.05或,P<0.01),镇痛试验结果显示,单次口服DK2.5～10.0mg·kg-1对小鼠热板法和扭体法呈显著或非常显著性镇痛作用(P<0.05或P<0.01),其抗炎和镇痛作用均明显强于阳性对照药扑炎痛。同时,对DK原粉的急性毒性试验结果显示,给予小鼠灌胃的LD50为(160.04±43.49)mg·kg-1,与腹腔注射途径所得LD50(182.58±30.64)mg·kg-1无显著差异。
OBJECTIVE: To evaluate the analgesic and anti-inflammatory effects of diclofenac potassium (DK) powder and its acute toxicity in mice and rats. Methods Carrageenan induced paw edema in rats, auricle swelling induced by xylene in mice, hot plate method and writhing method. Results: The results of anti-inflammatory test showed that single oral administration of DK5.0 ~ 20.0 mg · kg-1 significantly inhibited carrageenin-induced paw edema (P <0.05 or P <0.01), analgesia The results showed that a single oral DK2.5 ~ 10.0mg · kg-1 on the hot-plate method and writhing mice showed significant or very significant analgesic effect (P <0.05 or P <0.01), the anti-inflammatory and Analgesic effects were significantly stronger than the positive control agent Puff inflammation. At the same time, acute toxicity test on raw powder of DK showed that LD50 was (160.04 ± 43.49) mg · kg-1 in gavage mice and was no significant difference with LD50 (182.58 ± 30.64) mg · kg-1 in intraperitoneal injection difference.