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目的:探讨促性腺激素释放激素激动剂联合维生素E对子宫内膜异位症伴不孕女性血清肿瘤坏死因子(TNFα)及白介素-6(IL-6)水平的影响。方法:收集我院治疗的84例子宫内膜异位症伴不孕患者,随机分为实验组和对照组,每组42例。对照组患者给予促性腺激素释放激素激动剂治疗,实验组患者在对照组基础上给予维生素E治疗。观察并比较两组患者治疗前后血清TNF-α及IL-6水平、妊娠率以及临床疗效。结果:与治疗前比较,两组患者治疗后血清IL-6及TNF-α水平均下降,差异具有统计学意义(P<0.05);与对照组比较,实验组患者治疗后血清TNF-α及IL-6水平较低,差异具有统计学意义(P<0.05)。实验组患者治疗总有效率(92.86%)高于对照组(78.57%),差异具有统计学意义(P<0.05)。实验组患者妊娠率(71.43%)高于对照组(54.76),差异具有统计学意义(P<0.05)。结论:促性腺激素释放激素激动剂联合维生素E能够降低子宫内膜异位症伴不孕女性血清TNF-α及IL-6水平,提高患者的妊娠率,临床效果较好。
Objective: To investigate the effect of gonadotropin-releasing hormone agonist combined with vitamin E on serum tumor necrosis factor (TNF) and interleukin-6 (IL-6) levels in endometriosis-associated infertile women. Methods: Eighty-four patients with endometriosis and infertility who were treated in our hospital were randomly divided into experimental group and control group with 42 cases in each group. Patients in the control group were treated with gonadotropin-releasing hormone agonist. Patients in the experimental group were treated with vitamin E on the basis of the control group. The levels of serum TNF-α and IL-6, pregnancy rate and clinical efficacy before and after treatment in both groups were observed and compared. Results: Compared with those before treatment, the levels of serum IL-6 and TNF-α decreased after treatment in both groups (P <0.05). Compared with the control group, the levels of serum TNF-α and TNF- IL-6 levels lower, the difference was statistically significant (P <0.05). The total effective rate of treatment group (92.86%) was higher than that of control group (78.57%), the difference was statistically significant (P <0.05). The pregnancy rate (71.43%) in the experimental group was higher than that in the control group (54.76), the difference was statistically significant (P <0.05). CONCLUSION: The combination of gonadotropin-releasing hormone agonist and vitamin E can reduce the serum levels of TNF-α and IL-6 in patients with endometriosis and infertility, and improve the pregnancy rate of patients with better clinical outcomes.