为探讨贯叶金丝桃抗抑郁作用的机理,作者进行了体内、外试验,研究了该植物提取物对小鼠脑内五羟色胺传输、摄取及行为的影响。雄性ICR小鼠禁食16h后,分别口服贯叶金丝桃提取物(100、300和900mg/kg,相当于含贯叶金丝桃素30～300nmol/L)、舍曲林(10mg/kg)或帕罗西汀(lmg/kg);对照组小鼠服用赋形剂。在服药后1～12h,下 To investigate the mechanism of antidepressant effect of Hypericum perforatum, the authors conducted in vitro and in vivo experiments to study the effects of the plant extracts on the transmission, uptake and behavior of serotonin in the mouse brain. Male ICR mice were orally administered with Hypericum perforatum (100, 300, and 900 mg/kg, equivalent to 30 to 300 nmol/L of St. John’s Wort), sertraline (10 mg/kg), or paroxetine for 16 h after fasting. (lmg/kg); mice in the control group were given vehicle. 1~12h after medication