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目的了解来宾市健康人群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)的带菌状况,揭示优势菌群,评估流行性脑脊髓膜炎(流脑)流行风险,为制定流脑预防控制策略提供参考。方法将调查对象分为5个年龄组,每个年龄组至少调查200人。每个调查对象采集1份咽拭子,共采集1311份咽拭子进行Nm分离培养和血清群鉴定。结果2011年,来宾市健康人群Nm带菌率为8.54%,其中B群占31.25%,W135群占15.18%,C群占1.79%,A群、X群、Y群各占0.89%,不可分群占49.11%;青年人带菌率高于少年儿童,男性带菌率高于女性。同年来宾市发生的3例流脑均为W135群。结论来宾市健康人群Nm带菌以不可分群菌株为主,可分群菌株中以B群和W135群为优势菌群;W135群为来宾市流脑的主要流行菌群,应在继续推行A+C群脑膜炎球菌疫苗(Meningococcal Vacune,MenV)接种的同时,加强W135群MenV的接种,以期有效预防控制流脑疫情。
Objective To understand the carrier status of Neisseria meningitidis (Neisseria meningitidis) in Laibin city and to reveal the predominant flora and to evaluate the prevalence of epidemic cerebrospinal meningitis (CSF) in order to provide reference for the prevention and control strategies of meningococcal meningitis. Methods The subjects were divided into five age groups and at least 200 people were investigated in each age group. One throat swab was collected from each subject, 1311 throat swabs were collected for Nm isolation and serogroup identification. Results In 2011, the Nm-carrying rate of healthy population in Laibin city was 8.54%, including 31.25% in B group, 15.18% in W135 group and 1.79% in C group, 0.89% in A group, X group and Y group, respectively 49.11%. The incidence of young people was higher than that of children and boys. The incidence of male carriers was higher than that of women. The same year, Laibin City, 3 cases of meningitis are W135 group. Conclusion Nm-carrying bacteria in Laibin city are predominantly unbranched strains, but B and W135 are the dominant bacteria in the isolates. W135 is the major epidemic strain of melobacter in Laibin and should continue with A + C Meningococcal Vacune (MenV) inoculation, while strengthening the W135 MenV vaccination, in order to effectively prevent and control meningococcal epidemic.