人体抗肿瘤免疫是以T细胞介导的细胞免疫为主,B7分子及其受体传导的共刺激信号是T细胞活化增殖的重要辅助信号。干预共刺激途径,诱导T细胞肿瘤特异性免疫杀伤反应或诱导T细胞抗原特异性无能状态,是目前自身免疫疾病、肿瘤和器官移植治疗的研究热点。在血液系统恶性肿瘤的治疗领域,免疫基因治疗、肿瘤疫苗、抗B7-1单抗等的尝试正在积极展开。 Human anti-tumor immunity is based on T cell-mediated cellular immunity, co-stimulatory signal transduced B7 molecules and their receptors is an important auxiliary signal T cell activation and proliferation. Intervention of costimulatory pathway, induced T cell tumor-specific immune response or induction of T cell antigen-specific incapacitating state, is the current autoimmune diseases, cancer and organ transplantation research hotspot. In the field of hematological malignancies, immunotherapy, tumor vaccines, anti-B7-1 monoclonal antibodies and other attempts are being actively carried out.