采用多中心随机对照方法评价甲基强的松龙或纳络酮治疗脊髓损伤的效果。 487例脊髓损伤患者,其中427例(95％)患者随访一年。随机甲基强的松龙组(首剂30mg/kg,随后23小时每小时5.4 mg/kg)162例、纳络酮组(首剂5.4 mg/吨,随后23小时每小时4.0mg/kg)、安慰剂组171例。487例患者中不及半数的患者于损伤后直接送到脊髓损伤中心。绝大多数患者在入院前未接 A multicenter randomized controlled trial was conducted to evaluate the efficacy of methylprednisolone or naloxone in the treatment of spinal cord injury. Of the 487 spinal cord injury patients, 427 (95%) were followed up for one year. In the randomized methylprednisolone group (first dose of 30 mg / kg followed by 23 hours at 5.4 mg / kg), 162 were in the naloxone group (first dose of 5.4 mg / ton followed by 4.0 mg / kg at 23 hours) , 171 placebo group. Less than half of the 487 patients were delivered directly to the spinal cord injury center after the injury. The vast majority of patients did not receive before admission