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目的:探讨萎胃消颗粒对慢性萎缩性胃炎(CAG)模型大鼠血浆内皮素-1(ET-1)的影响。方法:将48只SPF级SD大鼠随机分为4组,即空白对照组、模型对照组、萎胃消治疗组和胃复春对照组,每组各12只。以饮用氨水法制备大鼠慢性萎缩性胃炎模型,空白对照组、模型对照组以蒸馏水灌胃,萎胃消组和胃复春组按生药804mg/d灌胃给药,连续用药8周,采用放射免疫法测定大鼠血浆ET-1水平。结果:与空白对照比较,模型组血浆ET-1含量升高(P<0.01);与模型组比较,萎胃消治疗组和胃复春对照组血浆ET-1含量均降低(P<0.01或P<0.05);与胃复春对照组比较,萎胃消颗粒组ET-1含量低,两组比较有统计学意义(P<0.01)。结论:萎胃消颗粒能够降低CAG大鼠血浆ET-1含量。
Objective: To investigate the effect of WeiWeiXiaoGai on plasma endothelin-1 (ET-1) in rats with chronic atrophic gastritis (CAG). Methods: 48 SPF SD rats were randomly divided into 4 groups: control group, model control group, Weiwei Xiaotherapy group and Weifuchun control group, with 12 rats in each group. The model of chronic atrophic gastritis was prepared by drinking ammonia method. The blank control group and the model control group were given gavage with distilled water. The rats in Weizhuxiao group and Weifuchun group were given gavage with 804mg / d of crude drug for 8 weeks. Radioimmunoassay was used to determine plasma ET-1 level in rats. Results: Compared with the blank control group, the content of ET-1 in the model group increased (P <0.01). Compared with the model group, the ET-1 level in the Weiwei Xia treatment group and the Wei Fuchun control group decreased P <0.05). Compared with Weifuchun control group, the content of ET-1 in Weiweixia pellet group was lower than that in Weifuchun Granules group (P <0.01). Conclusion: Weiweixiaowei can reduce plasma ET-1 level in CAG rats.