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人巨细胞病毒(CMV)是威胁人类健康的最重要病原之一。高CMV抗体效价的免疫球蛋白G(IgG)制剂,为临床医生在预防和治疗用药上提供了一个有价值的选择。而CMV免疫球蛋白标准品对于制品的CMV抗体效价测定以及高效价血浆的筛选都至关重要。该标准品对于器官移植/输血安全测试,以及临床诊断都是不可或缺。本综述提供了一种人巨细胞病毒IgG标准品制剂方法以及目前研究进展的概述。此外,本文还关注应用于不同领域的不同CMV IgG抗体效价单位。故本文为人巨细胞病毒免疫球蛋白的开发,人巨细胞病毒IgG抗体诊断试剂的标准化,以及为其质量控制提供参考。
Human cytomegalovirus (CMV) is one of the most important pathogens that threaten human health. Immunoglobulin G (IgG) preparations with high CMV antibody titers offer clinicians a valuable option in the prophylaxis and treatment of medication. The CMV immunoglobulin standard for the determination of CMV antibody titer of the product and the selection of high titer plasma are crucial. The standard for organ transplantation / blood transfusion safety testing, as well as clinical diagnosis are indispensable. This review provides an overview of methods for the preparation of human cytomegalovirus IgG standards and the current research advances. In addition, this article also focuses on different CMV IgG antibody titers used in different fields. Therefore, this article is the development of human cytomegalovirus immunoglobulin standardization of human cytomegalovirus IgG antibody diagnostic reagents, as well as provide a reference for its quality control.