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α病毒(Alphavirus)属于被膜病毒科,是单股正链RNA病毒,其家族多个成员已经被用作表达载体,广泛地应用于基因治疗和分子生物学研究领域。全文就α病毒载体生物学特性及其肿瘤基因治疗中的应用作一阐述。1基因治疗载体种类现阶段应用于肿瘤基因治疗的载体有病毒和非病毒载体两种,非病毒载体(如质粒脂质体)虽然具有构建简单、可标记等优点,但由于其转染率低,影响基因表达效果,因此现
Alphavirus belongs to the family of enveloped viruses and is a single-stranded positive-sense RNA virus. Several members of its family have been used as expression vectors and are widely used in the field of gene therapy and molecular biology. The full text of the biological characteristics of alphavirus vector and its application in gene therapy for cancer. 1 gene therapy vector types Currently used in cancer gene therapy vector virus and non-viral vectors are two, non-viral vectors (such as plasmid liposomes) although has the advantages of simple construction, labeling, etc., but because of its low transfection rate , Affect the effect of gene expression, so now