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目的:总结胶质瘤治疗的临床经验,探索胶质瘤综合治疗的方法。方法:回顾性分析296例胶质瘤病例资料,并进行随访。结果:296例胶质瘤中,Ⅰ～Ⅱ级胶质瘤114例,Ⅲ～Ⅳ级胶质瘤182例。全切除240例(81%),46例大部或部分切除,10例行活检。术后行常规放疗及替尼泊苷(VM-26)和MeCCNU化疗,术后随访178例,Ⅰ～Ⅱ级胶质瘤3年生存率达74.3%,Ⅲ～Ⅳ级胶质瘤只有12.5%。对于功能区和大脑深部的胶质瘤疗效不佳。结论:手术仍是胶质瘤治疗的基本手段,应尽量全切除肿瘤,术后放、化疗仍是必须。目前Ⅰ～Ⅱ级胶质瘤控制良好,但对于Ⅲ～Ⅳ级胶质瘤和功能区及深部胶质瘤疗效欠佳。
OBJECTIVE: To summarize the clinical experience of glioma treatment and to explore the method of comprehensive treatment of glioma. Methods: A retrospective analysis of 296 cases of glioma data and follow-up. Results: In 296 cases of gliomas, there were 114 cases of grade Ⅰ ~ Ⅱ gliomas and 182 cases of grade Ⅲ ~ Ⅳ gliomas. Total resection in 240 cases (81%), 46 cases of partial or partial resection, 10 cases of biopsy. Postoperative routine radiotherapy and teniposide (VM-26) and MeCCNU chemotherapy were followed up for 178 cases. The 3-year survival rates of grade Ⅰ-Ⅱ gliomas were 74.3%, and those of grade Ⅲ-Ⅳ gliomas were only 12.5% . For functional areas and deep brain gliomas curative effect is not good. Conclusion: Surgery is still the basic treatment of glioma, the tumor should be removed as much as possible, postoperative radiotherapy and chemotherapy is still necessary. Currently grade Ⅰ ~ Ⅱ glioma well controlled, but for grade Ⅲ ~ Ⅳ glioma and functional areas and deep gliomas poor efficacy.