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The Epstein-Barr virus (EBV) is consistently associated with nasopharyngeal non-keratinizing carcinoma (NKC). 1 Zong et ala reported that keratinizing squamous cell carcinoma (KSCC) is also closely related to EBV infection. The question of how many of the EBV infection rates are related to the adenosquamous carcinoma/mucoepidermoid carcinomas (ASC/MEC)and adenocarcinoma (AC) needs to be answered. Cheung et al3 reported that 92% (34/37) of nasopharyngeal carcinoma (NPCs), most of them might be NKCs harbored EBV with 30 bp-deleted LMP1 gene (delLMP1) in Hong Kong. Is this also the situation in Guangzhou? Are there any differences in the frequency of del-LMP1 EBV detected among four histological types of NPC? What is the role of del-LMP1 EBV playing in nasopharyngeal carcinogenesis? And this study aims at solving these issues.