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采用乙醇-水混合溶液为溶剂,以NaOH为沉淀剂制备了甲氨蝶呤(MTX)-镁铝层状双氢氧化物(Mg-Al-LDH)纳米复合材料,利用X-射线衍射(XRD)、透射电镜(TEM)和傅里叶变换红外(FT-IR)光谱等表征手段,对其结构及形貌进行了系统研究.研究表明,与传统的水溶液共沉淀法相比,醇水共沉淀法制备的MTX/LDH纳米复合物为球形片状,粒径较小,且分散性好.研究了醇水体积比对MTX/LDH纳米复合物性质的影响,结果表明,MTX分子以单层倾斜方式插入氢氧化物层间,随着合成条件的变化倾斜角度发生改变.当醇水体积比为1∶3时,制得的粒子最小,且大小均匀,无团聚现象.在磷酸缓冲液中考察了不同粒径MTX/LDH纳米复合物的缓释性能,结果表明,粒径小的MTX/LDH纳米粒子缓释效果优于粒径大的.
Methotrexate (MTX) - Mg-Al layered double hydroxides (Mg-Al-LDH) nanocomposites were prepared by ethanol-water mixed solvent with NaOH as precipitant. The XRD ), Transmission electron microscopy (TEM) and Fourier transform infrared (FT-IR) spectroscopy were used to characterize their structure and morphology. The results showed that compared with the traditional aqueous coprecipitation method, The MTX / LDH nanocomposites prepared by the method were spherical flakes with small particle size and good dispersibility.The effect of volume ratio of alcohol to water on the properties of MTX / LDH nanocomposites was investigated. The results showed that MTX molecules were single-layer tilted Way into the hydroxide layer, with the changes in the synthesis conditions change the tilt angle.When the volume ratio of alcohol to water is 1: 3, the smallest particle size, and uniform size, no agglomeration phenomenon in phosphate buffer solution The sustained release properties of MTX / LDH nanocomposites with different particle sizes showed that the sustained release of MTX / LDH nanoparticles with smaller particle size was better than the larger particle size.