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目的:探讨冠心病患者血清白介素18(Interleukin-18,IL-18)、白细胞分化抗原40配体(CD40L)、及高敏C反应蛋白(hs-CRP)水平在经皮冠状动脉介入术治疗前后的变化和意义。方法:选择经冠状动脉造影确诊的冠心病患者85例,根据病变程度分为单支病变组(n=32)、双支病变组(n=28)和多支病变组(n=25),采用双抗体夹心ELISA法测定PCI术前术后血清IL-18、CD40L和hs-CRP水平。结果:血清IL-18水平测定结果:多支病变组高于双支病变组,双支病变组高于单支病变组;支架置入术后显著高于术前,差异均有统计学意义(P<0.01)。血清CD40L水平测定结果:多支病变组高于双支病变组和单支病变组,差异均有统计学意义(P<0.01),双支病变组与单支病变组间差异无统计学意义(P>0.05);支架置入术后较术前显著升高,差异有统计学意义(P<0.01)。血清hs-CRP水平测定结果:多支病变组高于双支病变组,双支病变组高于单支病变组;支架置入术后显著高于术前,差异均有统计学意义(P<0.01)。结论:冠心病患者血清IL-18、CD40L和hs-CRP与冠脉病变程度密切相关,介入治疗可使冠心病患者血清IL-18、CD40L和hs-CRP水平升高,监测血清中IL-18、CD40L和hs-CRP水平变化可了解治疗效果和炎症程度。
Objective: To investigate the changes of serum interleukin 18 (IL-18), leukocyte differentiation antigen 40 ligand (CD40L) and high sensitivity C-reactive protein (hs-CRP) in patients with coronary heart disease before and after percutaneous coronary intervention Change and meaning. Methods: Totally 85 patients with coronary heart disease diagnosed by coronary angiography were divided into two groups according to the degree of lesion (n = 32), double-vessel lesion group (n = 28) and multivessel disease group (n = 25) Serum levels of IL-18, CD40L and hs-CRP were measured before and after PCI using double antibody sandwich ELISA. Results: The level of IL-18 in serum was significantly higher in multi-vessel disease group than in double-vessel disease group and double vessel disease group than in single vessel disease group (P <0.05). The difference was statistically significant P <0.01). Serum levels of CD40L were significantly higher in the multi-vessel disease group than in the double-vessel disease group and single-vessel disease group (P <0.01). There was no significant difference between the double-vessel disease group and the single vessel disease group P> 0.05). The stent placement was significantly higher than that before operation (P <0.01). Serum hs-CRP levels were measured: multi-vessel disease group was higher than the double-vessel disease group, double-vessel disease group was higher than the single vessel disease group; the stent was significantly higher than the preoperative, the difference was statistically significant (P < 0.01). Conclusion: Serum levels of IL-18, CD40L and hs-CRP in patients with coronary heart disease are closely related to the severity of coronary artery disease. Serum levels of IL-18, CD40L and hs-CRP in patients with coronary heart disease may be increased by interventional therapy. , CD40L and hs-CRP levels to understand the therapeutic effect and extent of inflammation.