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目的探讨腹部闭合性损伤所致小肠破裂早期外周血中肠脂肪酸结合蛋白(intestinal fatty acid binding protein,IFABP)的变化。方法随访腹部闭合性损伤患者36例,根据小肠是否破裂分为肠破裂组12例和未破裂组24例,采用ELISA法检测患者入院时、入院1、3h时血清IFABP水平,并进行2组间比较。结果肠破裂组患者血清IFABP水平在入院时[(134.41±53.34)μg/L]、入院1h[(174.68±69.06)μg/L]、入院3h[(186.65±90.08)μg/L]均明显高于未破裂组[(91.44±40.37)、(98.35±44.48)、(104.51±40.08)μg/L](P<0.05)。结论血清IFABP水平检测可用于腹部闭合性损伤所致小肠破裂的早期诊断。
Objective To investigate the changes of intestinal fatty acid binding protein (IFABP) in the early stage of intestine rupture induced by closed abdominal injury. Methods Totally 36 patients with abdominal closed injury were divided into 12 cases of intestinal rupture and 24 cases of rupture without rupture according to the rupture of the intestine. Serum levels of IFABP were measured by ELISA at 1 h and 1 h after admission, Compare Results The serum levels of IFABP in patients with intestinal rupture were significantly higher at admission (134.41 ± 53.34 μg / L), 1 h after admission (174.68 ± 69.06 μg / L) and 3 h after admission (186.65 ± 90.08 μg / L) (91.44 ± 40.37), (98.35 ± 44.48), (104.51 ± 40.08) μg / L] in the non-ruptured group (P <0.05). Conclusion The detection of serum IFABP levels can be used for the early diagnosis of intestinal rupture caused by closed abdominal injury.