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本文就吸烟影响药物作用或药物动态的代表药物,结合作者等的动物基础实验结果进行解说。基础实验主要介绍吸烟对临床常用口服支气管扩张药茶硷及抗溃疡药甲氰咪胍血中动态的影响。一、受吸烟影响的代表性药物已知吸烟会促进茶硷在肝脏中的代谢,使其在血中的半衰期(T1/2)缩短,增加清除率,即吸烟者比不吸烟者茶硷自血中消失快。吸烟对局麻药利多卡因的影响,一般认为吸烟者口服该药时的生物利用率比非吸烟者低,伹静脉给药时,吸烟对酶活性诱导的影响比较小。
In this paper, smoking on behalf of drug effects or drug effects of drugs, combined with the author of the animal basic experimental results to explain. The basic experiment mainly introduces the influence of smoking on the blood dynamics of theophylline and anti-ulcer drug Cimetidine, which are the commonly used oral bronchodilators in clinical practice. A representative drug affected by smoking It is known that smoking promotes the metabolism of theophylline in the liver, shortens its half-life in the blood (T1 / 2) and increases the clearance rate, ie, the smokers’ Quick disappearance of blood. The impact of smoking on local anesthetic lidocaine is generally believed that the bioavailability of smokers when taking this drug is lower than that of non-smokers. When administered intravenously, smoking has less effect on enzyme activity.