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糖尿病视网膜病变(DR)是糖尿病的严重并发症之一,也是主要致盲原因之一,对DR发病机制及有效防治的研究是该领域的重要课题.近年来,对哺乳动物细胞内沉默调节蛋白Sirtuins的研究进展迅速,并发现Sirtuins与多种代谢性疾病及年龄相关性疾病有关.在肿瘤、糖尿病肾病等疾病的研究中,Sirtuins已成为一大热点,Sirtuins与多种DR相关机制,包括缺氧、氧化应激、炎症等存在密切联系.本文对Sirtuins在DR中的作用做一综述,为理解DR的发病机制及制定治疗策略提供新的思路.“,”As one of the serious complications of diabetes melitus,diabetic retinopathy (DR) is one of the major causes of blindness.It is urgent to figure out the mechanism of DR and identify an effective therapeutic target to prevent it.Sirtuins is a major catabolic pathway involved in degrading and recycling damaged organelles and macromolecules to maintain intracellular homeostasis.The study of Sirtuins in mammalian systems has been advancing rapidly and revealed that Sirtuins is involved in the pathogenesis of various metabolic and age-related diseases.The study of Sirtuins in such diseases as tumors,diabetic nephropathy,has been currently under intense investigation.Moreover,there is also a close relationship between Sirtuins and DR related factors including hypoxia,oxidative stress,inflammation,and so on.In this paper,recent research progress in Sirtuins and its application in DR are reviewed,so as to provide a new perspective on pathogenesis and therapy of DR.