本文用示波极谱滴定法测定盐酸小檗碱及其制剂的含量。方法是:在醋酸盐缓冲溶液中(pH 4.3)盐酸小檗碱与过量四苯硼钠液反应,剩余Na-TPB液以硫酸亚铊滴定。测定结果:原料药的回收率为99.89±0.29％,片剂的回收率为99.46±0.32％。复方软膏剂则用环已烷溶解后,以水萃取进行测定。回收率为100.5±0.52％。本法测定所取的浓度小(10～40mg/40ml),且片剂糖衣及赋形剂不干扰测定。 In this paper, the determination of berberine hydrochloride and its preparations by oscillopolarographic titration method. The method is: in acetate buffer solution (pH 4.3) berberine hydrochloride and excess sodium tetraphenylborate reaction, the remaining Na-TPB titration with thallium sulfate titration. The results showed that the recovery rate of API was 99.89 ± 0.29% and the recovery rate of tablets was 99.46 ± 0.32%. Compound ointment is dissolved with cyclohexane after water extraction was measured. The recovery was 100.5 ± 0.52%. The method of determination of the concentration of small (10 ~ 40mg / 40ml), and the sugar coating and vehicle tablets do not interfere with the determination.