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本文报告了延胡索丑素和癸素的鎮靜鎮定作用,并与乙素作了比較,对它們的抗电休克和鎮痛作用也进行了試驗。获得的結果如下: (一)丑素与乙素都能加強戊巴比妥鈉20毫克/公斤阈下睡眠作用,它們使半数小白鼠入睡的有效剂量(ED_(50)),各为60和30毫克/公斤。用該剂量产生的睡眠时間各为27±4分和35±6分。丑素与乙素对小白鼠自发活动有抑制作用,其ED_(50)各为29和22毫克/公斤。它們还能对抗墨西卡林的作用,ED_(50)各为53与35毫克/公斤。丑素大剂量时也能对抗苯丙胺的毒性,但作用不及乙素明显,所以丑素的鎮靜鎮定作用不及乙素強。 (二)癸素的鎮靜鎮定作用和鎮痛效能均很弱。 (三)丑素和癸素无抗电休克作用。
This article reports the sedative and sedative effects of fumagilloxanthin and dextrins and compares them with those of b, and tests their anti-shock and analgesic effects. The results obtained are as follows: (1) Both ubiquinone and bilirubin potentiate 20 mg / kg subthreshold pentobarbital sleep, and the effective dose (ED 50) of half of them to sleep is 60 and 30 mg / kg. The sleep time generated with this dose was 27 ± 4 and 35 ± 6 minutes for each. Ubiquinone and berberine inhibited the spontaneous activity of mice, the ED_ (50) for each of 29 and 22 mg / kg. They are also able to counter the effects of mexacalin, with ED 50 each at 53 and 35 mg / kg. Ugly prime large doses can also be resistant to amphetamine toxicity, but the effect is less obvious than B, so ugly Su sedative stability than B strong. (B) serenin sedation and analgesic effect of sedation are very weak. (C) ugly element and no anti-Septal anti-shock effect.