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制剂中药品的氧化,大多属于连续的自动氧化。连锁反应的开始是由极少量的氧引起。即使密封在安瓿内的注射液,用惰性气体置换安瓿空间尚存的氧,仍不可能完全排除氧,即仍不能完全防止制剂的氧化,何况口服制剂,通常对空气是不密闭的。因此为了保护敏感成分在制剂中不受氧化,在制剂化过程中要选用适当抗氧剂。抗氧剂按作用方式可分为以下三类: (1)还原剂:采用氧化电位高的还原性物质作还原剂,使它先于易氧化的药品而迅
Preparation of Chinese medicine oxidation, mostly belonging to the continuous automatic oxidation. The beginning of the chain reaction is caused by a very small amount of oxygen. Even if the injection is sealed in ampoules, replacement of the oxygen remaining in the ampoule with inert gas is still impossible to completely exclude the oxygen, that is, the oxidation of the formulation can not be completely prevented, not to mention oral preparations, which are usually not air tight. Therefore, in order to protect the sensitive components in the formulation from oxidation, in the process of formulation should choose the appropriate antioxidant. Antioxidants according to the mode of action can be divided into the following three categories: (1) reducing agent: the use of reducing potential high oxidation potential reductant as a reducing agent to make it prior to the rapid oxidation of drugs