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目的探讨胃肠道神经内分泌癌的诊治及临床病理学特征。方法收集45例胃肠道神经内分泌癌的临床病理学资料,进行免疫组织化学染色,标记抗体为NSE、Syn和CgA。结果镜下观察Ⅰ型25例,Ⅱ型10例,Ⅲ型10例。组织学类型与淋巴结转移相关(χ2=4·05,P<0·05)。NSE、Syn和CgA的表达率分别为82%、71%和64%,其表达率与组织学类型无关(χ2=0·07、0·23、2·11,P>0·05)。Ⅰ型、Ⅱ型和Ⅲ型的5年生存率分别为70%、65%和52%。结论NSE、Syn和CgA的联合检测可协助诊断胃肠道神经内分泌癌,其组织学分类符合临床治疗与预后的需要。
Objective To investigate the diagnosis and treatment of gastrointestinal neuroendocrine carcinoma and its clinicopathological features. Methods The clinical and pathological data of 45 cases of gastrointestinal neuroendocrine carcinoma were collected and immunohistochemically stained. The labeled antibodies were NSE, Syn and CgA. Results In the microscope, there were 25 cases of type Ⅰ, 10 cases of type Ⅱ and 10 cases of type Ⅲ. Histological type was correlated with lymph node metastasis (χ2 = 4.05, P <0.05). The expression rates of NSE, Syn and CgA were 82%, 71% and 64%, respectively. The expression rates of NSE, Syn and CgA were not related to histological type (χ2 = 0.07,0.23,2.11, P> 0.05). The 5-year survival rates for type I, type II and type III were 70%, 65% and 52%, respectively. Conclusion The combined detection of NSE, Syn and CgA may be helpful in the diagnosis of gastrointestinal neuroendocrine carcinoma. The histological classification accords with the need of clinical treatment and prognosis.