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目的:探讨宫颈薄层液基细胞学技术(TLT)诊断宫颈上皮内瘤变(CIN)和宫颈癌的临床意义。方法:对7 526例患者行TLT检查,对宫颈不典型鳞状细胞(ASCUS)和腺细胞(AGUS)及ASCUS、AGUS以上病变进行活组织病理学检查。对活检为CINⅡ及CINⅡ以上的病变进行手术治疗。结果:TLT对宫颈癌前病变和宫颈癌的检出率为1.47%,TLT与组织病理检查的阳性符合率为75.28%,对高度CIN活检的病理诊断符合率为100%。阴道镜下宫颈活检与手术病理切片符合率为85.92%。结论:TLT诊断CIN和宫颈癌的可信度高,可广泛在经济较发达地区开展。
Objective: To investigate the clinical significance of cervical smear-based cytology (TLT) in the diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: Totally 7 526 patients underwent TLT examination. The pathological changes of cervical atypical squamous cells (ASCUS) and glandular cells (AGUS) and ASCUS and AGUS were examined by biopsy. Biopsy for CIN Ⅱ and CIN Ⅱ above lesions for surgical treatment. Results: The positive rate of TLT in cervical precancerous lesions and cervical cancer was 1.47%. The positive coincidence rate of TLT with histopathology was 75.28%. The coincidence rate of pathological diagnosis of high grade CIN biopsy was 100%. Colposcopic biopsy and surgical biopsy coincidence rate of 85.92%. Conclusion: The reliability of TLT in diagnosing CIN and cervical cancer is high and can be widely applied in economically developed areas.