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本文用RIA法测定352例胃镜病理诊断的胃十二指肠病患者之胃液、血清表皮生长因子(EGF)、生长抑素(SS)和胃泌素(GAS)水平。结果表明,胃液EGF水平在胃癌明显升高,在消化性溃疡降低;血清SS及GAS水平在各种胃十二指肠病中均显著高于正常对照,溃疡病的血清SS和GAS水平呈负相关趋势。各种胃病血清SS水平相近,胃液SS水平胃癌显著高于良性胃病,且胃癌胃液SS显著高于其血清SS水平。幽门螺杆菌(HP)感染不影响溃疡病的血清GAS和SS水平及慢性浅表性胃炎的血清SS水平,HP感染严重时慢性萎缩性胃炎的血清SS水平显著升高。
In this paper, gastric juice, serum epidermal growth factor (EGF), somatostatin (SS) and gastrin (GAS) levels were determined by RIA in 352 patients with gastroduodenal pathology. The results showed that gastric juice EGF levels were significantly increased in gastric cancer, peptic ulcer decreased; serum SS and GAS levels in various gastroduodenal diseases were significantly higher than the normal control, ulcer disease serum SS and GAS levels were negative Related trends. The levels of serum SS in various stomach diseases were similar, the levels of SS in gastric juice were significantly higher than those in benign gastric diseases, and the gastric juice SS in gastric cancer was significantly higher than that in serum SS. Helicobacter pylori (HP) infection does not affect the serum levels of GAS and SS in patients with ulcer disease and serum SS levels in chronic superficial gastritis, and serum SS levels in patients with chronic atrophic gastritis are significantly elevated in HP infection.