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3′-迭氮化物-3′去氧胸苷(zidovudine,AZT)可治疗 AIDS 或与 AIDS 有关疾病(ARC)时的人免疫缺损病毒(HIV)感染。1985年有人报告本药为50～500nmol/L 浓度时可抑制 HIV 复制。其影响 DNA终末链的合成,可将胸苷中的3′-羟基置换为迭氮化基而形成迭氮化胸苷。经细胞胸苷激酶的磷酸化后产
3’-Azide-3 ’zidovudine (AZT) treats human immunodeficiency virus (HIV) infection in AIDS or AIDS-related diseases (ARC). It was reported in 1985, the drug is 50 ~ 500nmol / L concentration can inhibit HIV replication. Its effect on the synthesis of DNA terminal chain, thymidine 3’-hydroxy can be replaced by azidation and formation of azidothymidine. After the thymidine kinase phosphorylation of cells produced