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目的观察穴位埋线联合α-干扰素治疗慢性乙型肝炎外周血T淋巴细胞亚群的变化,探讨慢性乙型肝炎更加有效的抗病毒疗法。方法选取慢性乙型肝炎患者150例作为研究对象,随机分为观察组和对照组,每组各75例。对照组给予α-干扰素500万U,隔天1次肌内注射,观察组在对照组基础上加用穴位埋线治疗,每2周1次,4周为1个疗程,连续治疗3个疗程。分别观察2组治疗前后T淋巴细胞亚群的变化。结果治疗后,观察组CD3+、CD4+、CD8+、CD4+/CD8+值均较治疗前升高(P<0.05);对照组除CD4+外,其余指标均较治疗前升高(P<0.05)。2组间治疗后CD3+、CD8+值比较差异无统计学意义(P>0.05);2组间治疗后CD4+、CD4+/CD8+值比较差异有统计学意义(P<0.05)。结论慢性乙型肝炎经穴位埋线联合α-干扰素治疗后可有效改善患者的免疫功能状态,提高机体免疫应答能力,值得临床进一步研究。
Objective To observe the changes of T lymphocyte subsets in the peripheral blood of chronic hepatitis B treated with catgut embedding combined with α-interferon and explore the more effective antiviral therapy for chronic hepatitis B. Methods A total of 150 patients with chronic hepatitis B were selected as study subjects and randomly divided into observation group and control group with 75 cases in each group. In the control group, interferon-α was given to 5 million U and intramuscularly in the other day. The observation group was treated with catgut embedding therapy on the basis of the control group, once every two weeks, four weeks as a course of treatment and three consecutive treatments Course of treatment. The changes of T lymphocyte subsets in two groups before and after treatment were observed. Results After treatment, the levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + in the observation group were significantly higher than those before treatment (P <0.05). All the other indexes in the control group were significantly higher than those before treatment (P <0.05). There was no significant difference in CD3 +, CD8 + between two groups after treatment (P> 0.05). The difference of CD4 +, CD4 + / CD8 + between the two groups after treatment was statistically significant (P <0.05). Conclusions Treatment of chronic hepatitis B with acupoint catgut embedding and a-interferon treatment can effectively improve the immune function of patients and improve the immune response ability of the body, which deserves clinical further study.