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传统的疾病诊断方法存在耗时长、工作量大、设备昂贵和操作复杂的缺点,因此很多检测只能在专业的大型医院和生物医学实验室完成.更重要的是由于不能及时地得到检查结果,将最终导致病人失去最佳的治疗时机.基层诊所和个人家庭最为需要的是低成本、操作简便的即时检测(point-of-care,POC)设备及技术.基于标准光盘/光驱的生物分子检测技术有可能成为新一代POC检测与诊断工具,不仅光盘塑料底片可以为生物芯片提供价格低廉的基底材料,而且光驱可以用作精密的信号读出装置.本文将概括介绍于化忠课题组在生物光盘检测系统开发和应用方面所取得的进展,包括光盘塑料基底表面活化技术的开发、生物检测光盘的制备、信号识别方法的建立,以及在医学化验和环境监测方面的应用开发.
Traditional methods of disease diagnosis have the disadvantages of long time consuming, heavy workload, expensive equipment and complicated operation, so many tests can only be done in professional large hospitals and biomedical laboratories.More importantly, because of the inability to obtain timely inspection results, Will eventually lead to the loss of patients the best timing of treatment.The primary need for low-cost, easy-to-use point-of-care (POC) devices and technologies in primary care and personal homes is the need for biomolecular testing based on standard CD / Technology may become a new generation of POC detection and diagnostic tools, not only disc plastic film can provide low-cost substrate for biochip material, and the optical drive can be used as a sophisticated signal readout device.This article will be introduced in general in the group of Zhongzheng biological The progress made in the development and application of optical disc detection systems includes the development of surface activation techniques for optical plastic substrates, the preparation of biopsy discs, the establishment of signal recognition methods, and the development of applications in medical assays and environmental monitoring.