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非典型病原体是中国社区获得性肺炎(CAP)的主要致病原之一,可以在所有年龄段人群中引起轻-中度疾病,而非典型病原体与细菌的混合感染与较高的病死率相关。在确定非典型病原体感染的基础上,如果患者同时有细菌感染的相应临床表现,呼吸道分泌物细菌培养阳性,可以考虑非典型病原体混合感染。临床在经验性治疗CAP时,如果不能排除非典型病原体混合感染,应选择抗菌谱可覆盖非典型病原的药物单用或联合应用。
Atypical pathogens are one of the major causative agents of community acquired pneumonia (CAP) in China and can cause mild to moderate disease in all age groups, whereas a combination of non-typical pathogens and bacteria is associated with a higher case fatality rate . In determining the atypical pathogens based on the infection, if the patient also has the corresponding clinical manifestations of bacterial infections, bacterial cultures of respiratory secretions positive, consider atypical pathogens mixed infection. Clinical experience in the treatment of CAP, if you can not rule out atypical pathogens mixed infection, antimicrobial spectrum should be selected to cover atypical pathogenic drugs alone or in combination.