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本文报道了胎肝细胞提取液的研制及临床疗效观察。作者将胎肝细胞低渗裂解后,经超速离心等将其部分纯化后制成胎肝细胞提取液,并将其中之蛋白质予以定量后,由药检部门经热原试验、过敏试验、急慢性毒性试验等均合格后,试用于恶性肿瘤化疗后粒细胞减少症患者观察其升白作用。结果表明,治疗组升白作用明显强于对照组,但对血色素、血小板的升高作用无统计学意义。文中还对该提取液的临床意义及可能机制进行了讨论。
This article reported the development of fetal liver cell extract and observation of clinical efficacy. After hypotonic lysing of fetal liver cells, the fetal liver cells were partially purified by ultracentrifugation to prepare fetal liver cell extracts. After the proteins were quantified, they were subjected to pyrogen test, allergy test, and acute and chronic toxicity. After the tests were passed, they were tested in patients with neutropenia after chemotherapy for malignant tumors to observe their effect. The results showed that the whitening effect of the treatment group was significantly stronger than that of the control group, but there was no statistically significant effect on the elevation of hemoglobin and platelets. The paper also discussed the clinical significance and possible mechanism of the extract.