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目的:探讨思连康制剂对新生儿高胆红素血症的治疗作用及免疫功能的影响。方法:将2007年10月～2008年11月住院的黄疸新生儿60例随机分为治疗组和对照组各30例,对照组采用常规的治疗,治疗组则在对照组的基础上加口服思连康制剂。观察两组患儿黄疸消退情况,并于治疗的第1和第7天分别检测患儿外周血的T细胞亚群和白细胞介素6(IL-6)和白细胞介素8(IL-8)的水平变化,同时检测20例正常儿T细胞亚群和白细胞介素6(IL-6)和白细胞介素8(IL-8)的水平,比较两种情况下治疗的效果及患儿免疫功能的变化。结果:口服思连康制剂能有效地促进新生儿黄疸的消退,且能调节黄疸新生儿的T细胞亚群表达和细胞因子的分泌水平。结论:口服思连康制剂对新生儿高胆红素有一定的辅助治疗作用,可能是通过增强细胞免疫功能来防治感染。
Objective: To investigate the therapeutic effect of Si Lian Kang on neonatal hyperbilirubinemia and its immune function. Methods: 60 newborns admitted to jaundice from October 2007 to November 2008 were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was treated with conventional therapy. The treatment group was treated with oral administration Lian Kang preparations. The regression of jaundice in both groups was observed. T-lymphocyte subsets, interleukin-6 (IL-6) and interleukin-8 (IL-8) in peripheral blood were detected on the 1st and 7th day of treatment, T cell subsets and IL-6 and IL-8 levels in 20 normal children were detected at the same time. The effects of treatment and immune function were compared between the two groups The change. Results: The oral siliceous preparation can effectively promote neonatal jaundice and regulate the expression of T lymphocyte subsets and the secretion of cytokines in neonatal jaundice. Conclusion: Oral siliceous preparations have certain adjuvant therapeutic effect on neonatal hyperbilirubin, which may be through the enhancement of cellular immune function to prevent infection.