为了解重组干扰素α２ｂ治疗慢性乙型肝炎疗效的影响因素，对住院治疗的１０８例慢性乙型肝炎进行研究。治疗前所有病例ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢＶＤＮＡ均阳性，ＡＬＴ均大于正常值３倍。结果发现，总有效率女性高于男性（Ｐ＜００５）；病程短于３年者明显优于长于３年者（Ｐ＜００１）；ＣＡＨ明显高于ＣＰＨ（Ｐ＜００１）。９例治疗无效者，２例检出前Ｃ区变异；１例野生株和变异株混合感染者疗程结束后表现为无效。４７例治疗无效者（包括部分复发者），检出干扰素中和抗体２例；结合抗体６例。治疗期间有类流感症状者显效率明显高于无反应者（Ｐ＜００１）；总有效率高于无反应者（Ｐ＜００５）。治疗中ＡＬＴ升高大于基值２倍以上者疗效更好（Ｐ＜００１）。结果表明，干扰素治疗慢性乙型肝炎疗效的影响因素较多。 In order to understand the factors that influence the efficacy of recombinant interferon α2b in the treatment of chronic hepatitis B, 108 cases of chronic hepatitis B treated in hospital were studied. All cases before treatment HBsAg, HBeAg, HBV DNA were positive, ALT were greater than normal 3 times. The results showed that the total effective rate in females was higher than that in males (P <005); those with durations less than 3 years were significantly better than those older than 3 years (P <001); CAH was significantly higher than those in females (P00101) ). 9 cases were ineffective, 2 cases were detected before the mutation in C area; 1 case of wild-type and mutant mixed infection after treatment showed no effect. 47 cases of ineffective treatment (including some relapse), detection of interferon neutralization antibody in 2 cases; 6 cases of antibody. During the treatment period, the effective rate of flu-like symptoms was significantly higher than that of non-responders (P <001). The total effective rate was higher than that of non-responders (P <005). Treatment of ALT increased more than 2 times the base value was better (P <0  01). The results show that interferon treatment of chronic hepatitis B more influential factors.