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目的研究复方中药制剂汉丹肝乐 (HDGL)抗胆汁性肝纤维化的作用。方法采用胆总管结扎诱导大鼠胆汁性肝纤维化 ,自造模之日起ig给予汉丹肝乐 0 .3～ 0 .8g kg,连续四周 ,检测肝损害的生化指标 ,肝组织做病理检查。结果汉丹肝乐明显减轻肝细胞病理改变 ,使AKP和ALT降低 ;肝胶原蛋白和丙二醛含量下降 ,尿羟脯氨酸排出量增加 ;血清黄疸指数、总胆红素和结合胆红素降低。结论汉丹肝乐具有减轻胆汁淤积 ,保护肝细胞 ,抗胆汁性肝纤维化的作用
Objective To study the anti-biliary hepatic fibrosis effect of compound traditional Chinese medicine preparation Handanganle (HDGL). Methods Biliary hepatic fibrosis was induced by common bile duct ligation. From the date of model establishment, ig was given to Handan Gan Le 0.3-0.8 g kg for four weeks to detect the biochemical indexes of liver damage. Liver tissue was examined pathologically. . RESULTS Handangangan significantly reduced the pathological changes of hepatocytes, decreased AKP and ALT, decreased the content of liver collagen and malondialdehyde, increased urinary hydroxyproline excretion, serum jaundice index, total bilirubin and conjugated bilirubin. reduce. Conclusion Handangangan has the effect of relieving cholestasis, protecting liver cells, and resisting biliary hepatic fibrosis