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以1-苯基-3-甲基-5-苯氧基-吡唑-4-甲醛和1-苯基-3-甲基-5-对甲苯氧基-吡唑-4-甲醛为原料,在碱性条件下与苯乙酮(取代苯乙酮)发生羟醛缩合,合成出10种新型含吡唑基的查尔酮;再用此查尔酮与邻氨基硫酚在冰醋酸中反应,合成了10种新的1,5-苯并硫氮杂,化合物的结构经元素分析、IR和1HNMR确认,同时测定了化合物6c的晶体结构.化合物6c属单斜晶系(Monoclinic),空间群P2(1)/n,晶胞参数a=1.1793(2)nm,b=1.1907(2)nm,c=1.8726(4)nm,α=90°,β=104.71(3)°,γ=90°,M=522.04,V=2.5432(9)nm3,D=1.363Mg/m3,Z=4,F(000)=1088.
Starting from 1-phenyl-3-methyl-5-phenoxy-pyrazole-4-carbaldehyde and 1-phenyl-3-methyl-5-p-tolyloxy-pyrazole- In alkaline conditions with acetophenone (substituted acetophenone) aldol condensation occurred, the synthesis of 10 new pyrazole-containing chalcone; and then this chalcone and o-aminothiophenol in acetic acid reaction , And ten new 1,5-benzothiazepines were synthesized.The structures of the compounds were confirmed by elemental analysis, IR and 1HNMR, and the crystal structure of compound 6c was also determined.Compound 6c belongs to monoclinic, Space group P2 (1) / n, cell parameters α = 1.1793 (2) nm, b = 1.1907 (2) nm, c = 1.8726 (4) nm, α = 90 °, β = 104.71 = 90 °, M = 522.04, V = 2.5432 (9) nm3, D = 1.363 Mg / m3, Z = 4, F (000) = 1088.