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磷脂酶A2(phospholipase A2,PLA2)是参与细胞代谢活动、信号转导等过程的重要酶类之一,广泛分布于哺乳动物机体内。随着对磷脂酶A2研究的深入,目前已有30余种磷脂酶A2亚型被逐一鉴定,磷脂酶A2亚型与男性生殖相关性研究也有了新的发现。该文通过对磷脂酶A2的最新亚型分类及其特征、磷脂酶A2在男性生殖系统中的分布、磷脂酶A2参与精子顶体反应及其信号转导通路以及与男性生殖相关的磷脂酶A2亚型等内容进行分析,研究磷脂酶A2在男性生殖系统中发挥的作用及其机制,为男性不育的诊断和治疗提供理论依据和思路策略。
Phospholipase A2 (PLA2) is one of the important enzymes involved in cellular metabolic activities and signal transduction. It is widely distributed in mammals. With the further research on phospholipase A2, more than 30 kinds of phospholipase A2 subtypes have been identified one by one, and the relationship between phospholipase A2 subtype and male genitalia has also been newly discovered. Through the classification of phospholipase A2 and its characteristics, distribution of phospholipase A2 in the male reproductive system, phospholipase A2 involved in sperm acrosome reaction and its signal transduction pathway and male reproductive-related phospholipase A2 Subtypes and other content of the analysis of phospholipase A2 in the male reproductive system play a role and mechanism for the diagnosis and treatment of male infertility provide a theoretical basis and ideas and strategies.