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目的:以硫酸庆大霉素与呋喃唑酮为主药配制的复方庆大霉素混悬剂,同时考察该制剂的检验方法及稳定性。方法:用紫外分光光度法和抗生素微生物二剂量检定法分别测定呋喃唑酮和硫酸庆大霉素的含量。结果:两种主药的平均回收率分别为99.3％(RSD=0.6％)和100.8％(RSD=0.5％)。结论:该制剂的配制及质控方法可行。
OBJECTIVE: To establish a gentamicin suspension containing gentamycin sulfate and furazolidone as the main drug, and to examine the test method and stability of the compound. Methods: The contents of furazolidone and gentamicin sulfate were determined respectively by UV spectrophotometry and two-dose antibiotic microbiological assay. Results: The average recoveries of the two main drugs were 99.3% (RSD = 0.6%) and 100.8% (RSD = 0.5%), respectively. Conclusion: The formulation and quality control methods are feasible.