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本实验将40只家兔随机分为两组:脾切除组和对照组(每组20只),在术前和术后20～30天内观察检测了红细胞数,“痘痕”红细胞数及红细胞免疫活性——红细胞C_3b受体花环率等。结果发现脾切除的动物“痘痕”红细胞明显增多,红细胞C_3b受体花环率显著降低,两者呈负相关。这表明脾脏不但对红细胞形态结构具有重要作用,而且通过这种作用还将影响其免疫粘附功能。由于脾切除后红细胞C_3b受体活性变化比“痘痕”红细胞更灵敏、迅速,因此红细胞C_3b受体的检测可能为临床评价脾功能提供一新的指标。
In this study, 40 rabbits were randomly divided into two groups: splenectomy group and control group (20 in each group). The number of red blood cells, the number of red blood cells and the number of red blood cells Activity - erythrocyte C_3b receptor rosette rate and so on. The results showed that there was a significant increase in “pox” erythrocytes in splenectomized animals, a significant decrease in the rosette of erythrocyte C_3b receptors, and a negative correlation between the two. This shows that the spleen not only has an important role on the morphology of erythrocytes, but also affects its immune adhesion function through this effect. Because the change of erythrocyte C_3b receptor activity after splenectomy is more sensitive and rapid than that of “pox” erythrocytes, the detection of erythrocyte C_3b receptor may provide a new index for clinical evaluation of splenic function.