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目的探讨慢性乙型肝炎(乙肝)患者血清铁蛋白(SF)含量与肝脏受损之间的关系。方法 2014年7月-10月检测98例慢性乙肝患者的SF,检测血清乙肝病毒(HBV)DNA载量(HBV-DNA),统计分析不同HBVDNA载量组间SF水平的差异,并将SF与甲胎蛋白及肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白、白蛋白、总胆红素、乙肝血清标志物乙肝表面抗原、乙肝表面抗体、乙肝e抗原、乙肝e抗体、乙肝核心抗体进行相关性分析。结果 98例慢性乙肝患者SF升高异常率为53.06%、SF升高者的SF浓度为(878.69±837.98)ng/m L;HBV-DNA低载量与高载量两组间SF均数比较差异有统计学意义(P<0.05);SF与ALT、AST、总胆红素呈正相关(P值均<0.01),与总蛋白、白蛋白呈负相关(P值均<0.01)。结论慢性乙肝患者的SF升高程度与肝损伤密切相关,可反映机体的炎症状态。
Objective To investigate the relationship between serum ferritin (SF) and liver damage in patients with chronic hepatitis B (hepatitis B). Methods From July to October 2014, SF was detected in 98 patients with chronic hepatitis B, the serum HBV DNA (HBV-DNA) was detected, and the differences in SF levels among different HBV DNA load groups were statistically analyzed. SF and Alpha-fetoprotein and liver function indicators ALT, AST, total protein, albumin, total bilirubin, hepatitis B serum markers hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B e antigen, hepatitis B e antibody , Hepatitis B core antibody correlation analysis. Results The abnormal increase rate of SF in 98 patients with chronic hepatitis B was 53.06%, SF was (878.69 ± 837.98) ng / m L in patients with elevated SF; SF mean of HBV-DNA between low and high load (P <0.05). There was a positive correlation between SF and ALT, AST and total bilirubin (P <0.01), but negatively correlated with total protein and albumin (P <0.01). Conclusion The level of SF in patients with chronic hepatitis B is closely related to liver injury, which can reflect the inflammatory state of the body.